Customs officers in Ireland have sized 2,253kg of suspected cocaine – which could be worth 157 million euros (£136m).
The haul was seized from a cargo vessel off the southeast coast of Ireland.
It comes after an elite Irish army unit stormed the Panamanian ship.
Speaking at a media briefing in Dublin on Wednesday, a spokesman for the Irish police service An Garda Siochana said: “This is the largest drug seizure in the history of the State.”
Assistant Commissioner Justin Kelly described the action as “hugely significant”.
Mr Kelly, from the Organised and Serious Crime Unit, said: “It shows our unrelenting determination to disrupt and dismantle networks, which are determined to bring drugs into our country.
“These groups are transnational groups. They are working all across the world and, because of that, we need to work with our international partners.”
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